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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. 프라그마틱 공식홈페이지 are often characterized by a focus on practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographic areas. This type of heterogeneity that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however could cause issues with the trial design.
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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They are also a good way to identify the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used as a substitute for explanatory studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study, including recruitment, design, delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.